The design and green nanofabrication of noble hydrogel systems with encapsulation of doped bioactive hydroxyapatite toward sustained drug delivery

Finding a bioactive hybrid material with the potential for controlled drug release has been one of major targets tissue engineering in recent years. In this line, present work describes new approach producing singular hydrogel microparticles (HMPs) different morphologies and compositions by combining experimental computational methods. Calcium-Alginate (Ca-ALG) core–shell Alginate-Chitosan microspheres (Ca-ALG-CHI) were synthesized presence drug-doped Hydroxyapatite (HA) their inner matrix. The methodology relies on use microfluidic system to obtain crosslinked HMPs homogeneous sizes morphologies, integrating external internal gelation. impact water-to-oil volume ratio, as well variations collecting baths, morphology, dispersion, considered. models chosen Propranolol hydrochloride Cloxacillin sodium salt monohydrate. Avrami's parameters used study address adsorption kinetics each onto HA, Korsmeyer-Peppas model was analyze posterior desorption profiles. conception development type improved functionalities are essential creation granular hydrogels, which an innovative, green, sustained highly promising solution therapies regenerative medicine areas.